Selected Publications

​2023

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Nature
Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W, Watts GFM, Weisenfeld D, Nayar S, Rangel-Moreno J, Meednu N, Marks KE, Mantel I, . . .; Accelerating Medicines Partnership: RA/SLE Network; Moreland LW, Goodman SM, Perlman H, Holers VM, Liao KP, Filer A, Bykerk VP, Wei K, Rao DA, Laura T. Donlin, Anolik JH, Brenner MB, Raychaudhuri S.

Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis
Science Immunology
Runci Wang, Anvita Singaraju, Kathryne E. Marks, Lorien Shakib, Garrett Dunlap, Ifeoluwakiisi Adejoorin, Stinne R. Greisen, Lin Chen, Aidan K. Tirpack, Carlos Aude, Miriam R. Fein, Derrick J. Todd, Lindsey MacFarlane, Susan M. Goodman, Edward F. DiCarlo, Elena M. Massarotti, Jeffrey A. Sparks, A. Helena Jonsson, Michael B. Brenner, Michael A. Postow, Karmela K. Chan, Anne R. Bass, Laura T. Donlin, Deepak A. Rao

Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis
​Nature Immunology
Smith MH, Gao VR, Periyakoil PK, Kochen A, DiCarlo EF, Goodman SM, Norman TM, Laura T. Donlin, Leslie CS, Rudensky AY.

Emerging synovial cell states in rheumatoid arthritis as potential therapeutic targets
​Current Opinion in Rheumatology
Ian Mantel, Miriam R Fein, Laura T Donlin  

Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation
Arthritis Research & Therapy
Bella Mehta, Susan Goodman, Edward DiCarlo, Deanna Jannat-Khah, J. Alex B. Gibbons, Miguel Otero, Laura T. Donlin, Tania Pannellini, William H. Robinson, Peter Sculco, Mark Figgie, Jose Rodriguez, Jessica M. Kirschmann, James Thompson, David Slater, Damon Frezza, Zhenxing Xu, Fei Wang & Dana E. Orange

Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis
Nature Communications
Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis & William H. Robinson

​2022

Inching closer to precision treatment for rheumatoid arthritis
Nature Medicine 
Laura T. Donlin ​

Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression 
Cell Reports
Nida Meednu, Javier Rangel-Moreno, Fan Zhang, Katherine Escalera-Rivera, Elisa Corsiero, Edoardo Prediletto, Edward DiCarlo, Susan Goodman, Laura T. Donlin, Soumya Raychauduri, Michele Bombardieri, Costantino Pitzalis, Dana E. Orange, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Andrew McDavid, and Jennifer H. Anolik

Neoplastic synovial lining cells that coexpress podoplanin and CD90 overproduce CSF-1, driving tenosynovial giant cell tumor 
Journal of Orthopaedic Research
​Andrew C Chandler, Mohamed Yakoub, Tomohiro Fujiwara, Laura T Donlin, Paul Edward Purdue, John H Healey​

2021

Sequencing of Circulating Microbial Cell-Free DNA Can Identify Pathogens in Periprosthetic Joint Infections
Journal of Bone and Joint Surgery
Adriana P Echeverria, Ian S Cohn , David C Danko, Sara Shanaj, Lily Blair , Desiree Hollemon , Alberto V Carli , Peter K Sculco , Carine Ho , Galit Meshulam-Simon , Christine Mironenko , Lionel B Ivashkiv , Susan M Goodman , Alexandra Grizas , Geoffrey H Westrich , Douglas E Padgett , Mark P Figgie , Mathias P Bostrom , Thomas P Sculco , David K Hong , Matthew S Hepinstall , Thomas W Bauer , Timothy A Blauwkamp , Barry D Brause , Andy O Miller, Michael W Henry, Asim A Ahmed , Michael B Cross , Christopher E Mason, Laura T Donlin 

IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation
Genome Medicine
​Fan Zhang, Joseph R. Mears, Lorien Shakib, Sara Shanaj, Ilya Korsunsky, Aparna Nathan, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Laura T. Donlin and Soumya Raychaudhuri

2020

Notch signalling drives synovial fibroblast identity and arthritis pathology
Nature
​Kevin Wei, Ilya Korsunsky, Jennifer L Marshall, Anqi Gao, Gerald F M Watts, Triin Major, Adam P Croft, Jordan Watts, Philip E Blazar, Jeffrey K Lange, Thomas S Thornhill, Andrew Filer, Karim Raza, Laura T Donlin, Accelerating Medicines Partnership Rheumatoid Arthritis & Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Christian W Siebel, Christopher D Buckley, Soumya Raychaudhuri, Michael B Brenner

Fibroblast subtypes in tissues affected by autoimmunity: with lessons from lymph node fibroblasts 
Current Opinion in Immunology
​William D Shipman, Marvin J Sandoval, Keila Veiga, Laura T Donlin, Theresa T Lu

2019

​​​HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness
Science Translational Medicine
David Kuo, Jennifer Ding, Ian Cohn, Fan Zhang, Kevin Wei, Deepak Rao, Cristina Rozo, Upneet K Sokhi, Accelerating Medicines Partnership RA/SLE Network, Edward F. DiCarlo, Michael B. Brenner, Vivian P. Bykerk, Susan M. Goodman, Soumya Raychaudhuri, Gunnar Rätsch, Lionel B. Ivashkiv, Laura T. Donlin.

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry 
​Nature Immunology
Fan Zhang, Kevin Wei, Kamil Slowikowski, Chamith Y. Fonseka, Deepak A. Rao, Stephen Kelly, Susan M Goodman, Darren Tabechian, Laura B. Hughes, Karen Salomon-Escoto, Gerald F. M. Watts, William Apruzzese …, Laura T. Donlin, Jennifer H. Anolik, Michael B. Brenner, Soumya Raychaudhuri.
| Data Set |

Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission
Arthritis Rheumatology
Dana E Orange, Phaedra Agius, Edward F DiCarlo, Serene Z Mirza, Tania Pannellini, Jackie Szymonifka, Caroline S Jiang, Mark P Figgie, Mayu O Frank, William H Robinson, Laura T Donlin, Cristina Rozo, Ellen M Gravallese, Vivian P Bykerk, Susan M Goodman
| Data Set |

​Increased Staphylococcus aureus Nasal Carriage Rates in Rheumatoid Arthritis Patients on Biologic Therapy
The Journal of Arthroplasty
Goodman SM, Nocon AA, Selemon NA, Shopsin B, Fulmer Y, Decker ME, Grond SE, Donlin LT, Figgie MP, Sculco TP, Russell LA, Henry ME, Bass AR, Miller AO, Sculco PK.
| Data Set |

Insights into rheumatic diseases from next-generation sequencing 
Nature Reviews Rheumatology
Laura T Donlin, Sung-Ho Park, Eugenia Giannopoulou, Aleksandra Ivovic, Kyung-Hyun Park-Min, Richard M Siegel, Lionel B Ivashkiv 
| Data Set |

Synovial Tissue: Cellular and Molecular Phenotyping
​Current Rheumatology Reports
Shanaj S, Donlin LT
| Data Set |

2018

Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue 
​Journal of Arthritis Research and Therapy
Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, …, Jennifer H. Anolik
| In the Press | Massive NIH–industry project opens portals to target validation

Flares in Patients with Rheumatoid Arthritis after Total Hip and Total Knee Arthroplasty: Rates, Characteristics, and Risk Factors. 
​The Journal of Rheumatology
Susan M. Goodman, Vivian P. Bykerk, Edward DiCarlo, Ryan W. Cummings, Laura T. Donlin, Dana E. Orange, Annie Hoang, Serene Mirza, Michael McNamara, Kayte Andersen, Susan J. Bartlett, Jackie Szymonifka and Mark P. Figgie

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. 
Nature Communications
Fumitaka Mizoguchi, Kamil Slowikowski, Kevin Wei, Jennifer L. Marshall, Deepak A. Rao, Sook Kyung Chang, Hung N. Nguyen, Erika H. Noss, Jason D. Turner, Brandon E. Earp, Philip E. Blazar, John Wright, Barry P. Simmons, Laura T. Donlin, …, Michael B. Brenner
| Data Set |

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation. 
Nature Communications
William Stephenson, Laura T. Donlin, Andrew Butler, Cristina Rozo, Bernadette Bracken, Ali Rashidfarrokhi, Susan M. Goodman, Lionel B. Ivashkiv, Vivian P. Bykerk, Dana E. Orange, Robert B. Darnell, Harold P. Swerdlow & Rahul Satija.
| Data Set |
| In the Press |  3-D Printed Instrument Expands Options For RA Tests, Treatments
| In the Press | New device for low-cost single-cell analysis identifies fibroblast subtypes in rheumatoid arthritis patients

​Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.​ 
​Arthritis and Rheumatology
Dana E. Orange, Phaedra Agius, Edward F. DiCarlo, Nicolas Robine, Heather Geiger, Jackie Szymonifka, Michael McNamara, Ryan Cummings, Kathleen M. Andersen, Serene Mirza, Mark Figgie, Lionel B. Ivashkiv, …, Laura T. Donlin.
| Data Set |

​Mixed Effects Association of Single Cells Identifies an Expanded Th1-Skewed Cytotoxic Effector CD4+ T Cell Subset in Rheumatoid Arthritis​ 
Science Translational Medicine
Chamith Y. Fonseka, Deepak A. Rao, Nikola C. Teslovich, Susan K. Hannes, Kamil Slowikowski, Michael F. Gurish, Laura T. Donlin, Michael E. Weinblatt, Elena M. Massarotti, Jonathan S. Coblyn, Simon M. Helfgott, Derrick J. Todd, Vivian P. Bykerk, Elizabeth W. Karlson, Soumya Raychaudhuri.

≤ 2017

​Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. 
Nature
​Deepak A. Rao, Michael F. Gurish, Jennifer L. Marshall, Kamil Slowikowski, Chamith Y. Fonseka, Yanyan Liu, Laura T. Donlin, Lauren A. Henderson, Kevin Wei, Fumitaka Mizoguchi, Nikola C. Teslovich, Michael E. Weinblatt,  …, Michael B. Brenner.

​Modulation of TNF-induced macrophage polarization by synovial fibroblasts. 
​The Journal of Immunology
Laura T. Donlin, Arundathi Jayatilleke, Eugenia G. Giannopoulou, George D. Kalliolias and Lionel B. Ivashkiv.
| Data Set |

​Regulation of type I interferon responses. 
Nature Reviews Immunology
Lionel B. Ivashkiv, and Laura T. Donlin.

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. 
Genes & Development
Laura T. Donlin, Christian Andresen, Steffen Just, Eugene Rudensky, Christopher T. Pappas, Martina Kruger, Erica Y. Jacobs, Andreas Unger, Anke Zieseniss, Marc-Werner Dobenecker, Tobias Voelkel, ..., Wolfgang A. Linke.

Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. 
​Journal of Experimental Medicine
Nichole M. Danzl, Laura T. Donlin, and Konstantina Alexandropoulos.

​Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation. 
​Molecular and Cellular Biology
Laura T. Donlin, Nichole M. Danzl, Celestine Wanjalla, and Konstantina Alexandropoulos.

The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability. 
​Molecular and Cellular Biology
Luzhou Xing, Laura T. Donlin, Rebecca H. Miller, and Konstantina Alexandropoulos.
​

Sin: good or bad? A T lymphocyte perspective.​  
​Immunological Reviews
Alexandropoulos K, Donlin LT, Xing L, Regelmann AG.

​Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin. 
​The Journal of Immunology
Donlin LT, Roman CA, Adlam M, Regelmann AG, Alexandropoulos K.

Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. 
​PNAS
Angelastro JM, Klimaschewski L, Tang S, Vitolo OV, Weissman TA, Donlin LT, Shelanski ML, Greene LA.